Medication Management Insights & Resources | Mosaic

Webinar: Improving medication use in a complex and vulnerable Medicare population

Written by Rosa Arumugam | Sep 22, 2026, 5:52:07 PM

On September 22 at 2pm EST, RxAnte and Mosaic Pharmacy Service will be co-presenting a webinar titled “Improving medication use in a complex and vulnerable Medicare population,” focusing on the role that a tech-enabled pharmacy can play in enhancing care for the most at-risk members of an MAPD population.

Read the case study below for a preview of what we’ll explore in our hour-long webinar and register here to join the event.

Medicare members who are “medically complex” – treating multiple chronic conditions with several maintenance medications – experience unique pharmacy challenges. They may have difficulty with activities such as organizing and remembering to take medications, traveling to the pharmacy, or affording the prescribed regimen. They are also at greater risk of polypharmacy-related adverse drug events.

UPMC Health Plan has partnered with Mosaic Pharmacy Service to offer a comprehensive pharmacy intervention to this population with the goal of improving medication use, clinical quality, and downstream medical costs.

Mosaic is a comprehensive, home-based pharmacy service that makes taking multiple daily medications safer, simpler, and more affordable for complex Medicare members.

“Mosaic is transforming the pharmacy experience at a critical time for vulnerable seniors while helping us achieve our business objectives. We look forward to expanding the service and broadening its impact at UPMC.” – Chronis Manolis, Chief Pharmacy Officer, UPMC Health Plan

Design

The collaboration between UPMC and Mosaic began in December 2019. Performance is being evaluated using a non-randomized, propensity-matched controlled design. Enrollees were matched to non-enrolled members with similar demographics, medical and pharmacy cost burden, and medication regimen characteristics.

Eligibility was based upon drug therapy burden, risk of medication non-adherence, and members in need of medication therapy management. A total of 349 members were enrolled during the first four months, using live telephonic outreach from the UPMC Health Plan pharmacy contact center. The measurement period included a 180-day look-back period prior to enrollment and a 90-day post-enrollment window. Measurement of longer term outcomes is ongoing. The following outcomes were measured:

  • Adherence: Improvement in triple-weighted CMS Star Ratings measure for oral diabetes medications, RAS antagonists, and statins
  • Prescribing: Polypharmacy / high-risk medication quality measure performance
  • Potential cost savings
  • Member satisfaction

Intervention

Eligible members expressing interest in the Mosaic service were offered enrollment. Once enrolled, Mosaic interviewed each member about their medication beliefs, medical history, current medication regimen, Therapeutic Decision Support™ software, tailored to the member’s drug plan. Mosaic provided the following services to enrolled members:

  • Reconciliation of medications on hand with those on health plan claims history
  • Clinical reviews of medication regimen supported by proprietary analytic of health plan claims data
  • Coordination with prescribers to optimize regimen based on identified safety, effectiveness, and cost savings opportunities
  • Monthly medication delivery in adherence packaging
  • Ongoing medication counseling
  • 24×7 pharmacist availability

Results

90 days after initial medication reconciliation and first medication fill, health plan clients and their members experienced the following outcomes:

  • 5.1% increase in the proportion of adherent members across 3x weighted Part D adherence measures
  • 50% reduction in fills of high-risk medications
  • 87% of members indicated they would recommend Mosaic to a relative or friend

Additionally, while optimizing medication regimens for Mosaic members, we were able to provide the following cost-saving and prescribing benefits:

  • $271 in annualized out-of-pocket savings to our members
  • $801 in annualized savings to the health plan
  • 44% of members were eligible for at least one deprescribing opportunity

“My blood sugar’s been great since you talked to my endocrinologist. She has been adjusting the dose and my blood sugar has stayed under 200. How were you able to save me all that money? Thank you for your help. This is such a great program.” – Robert (member), Pittsburgh, PA

Interested in learning more? Contact us today to discover how we can help you and your highest-risk members find simplicity, safety, and cost savings through improved medication use.